|

Follow Us:

Indeed Logo
mobile-logo
 

MBF Bioscience News

MBF Bioscience >  Blog
February 11, 2016

Genetic Mutation Accelerates CTE Pathology

by Pasang
in Scientific Applications & Use Cases, Software & Microscope Integrated Systems, Stereo Investigator®, MBF Products & Service Solutions, Additional Subject Matter, Stereology, Optical Fractionator
Comments

[caption id="attachment_6175" align="aligncenter" width="480"] Phosphorylated tau pS422 immunoreactive profiles (dark brown) in the cortex of P301S mice after repetitive mild TBI. Image courtesy of Dr. Leyan Xu, Department of Pathology, Johns Hopkins University.[/caption]   Over the course of a football game or a boxing match, athletes may experience a series of mild concussions. Some of these athletes develop a condition known as chronic traumatic encephalopathy (CTE), a...

Read More
December 4, 2015

The U.S. Small Business Administration Publishes MBF Bioscience Success Story

by Pasang
in Company News, Scientific Applications & Use Cases, Additional Subject Matter, Neuron Reconstruction
Comments

  The U.S. Small Business Administration recently published a success story about MBF Bioscience. The article highlights our success using federal Small Business Innovation Research (SBIR) grants to develop innovative products that help advance science. MBF Bioscience has a distinguished R&D program that develops cutting-edge tools for scientific research.   The SBIR grants have helped MBF Bioscience develop tools such as Neurolucida, the most widely used system for...

Read More
December 1, 2015

New Software Released for Automated Neuron Reconstruction and Analysis

by Pasang
in Software Applications For Quantitive Analysis, Neurolucida®, Company News, Software & Microscope Integrated Systems, Scientific Applications & Use Cases, MBF Products & Service Solutions, Additional Subject Matter, Neurolucida®360, 3D Reconstruction, Neuron Reconstruction
Comments

How the brain works and how the brain is affected by disease are mysteries in large part because neurons are so dynamic, numerous, and complex. Neurolucida 360, a revolutionary, new software product from MBF Bioscience, enables neuroscientists to uncover more information about neurons at a faster rate.   “Neurolucida 360 is a technological revolution” says Jack Glaser, President of MBF Bioscience. “It is the state-of-the-art tool for neuroscientists to analyze...

Read More
November 11, 2015

Dying neurons in Alzheimer’s patients show signs of improvement after gene therapy

by Pasang
in Scientific Applications & Use Cases, Software & Microscope Integrated Systems, Stereo Investigator®, MBF Products & Service Solutions, Additional Subject Matter, Alzheimer’s Disease, Stereology
Comments

[caption id="attachment_6094" align="alignright" width="231"] Micrograph of cholinergic neurons in the nucleus basalis of Meynert. Image from Wikipedia.[/caption]   Cholinergic neurons degenerate at devastating rates in Alzheimer's disease, but Dr. Mark Tuszynski and his team at the University of California, San Diego may have found a way to slow the decline.   Their study, published in JAMA Neurology, reports that nerve growth factor gene therapy increased the size, axonal sprouting, and signaling of cholinergic neurons...

Read More
August 18, 2015

Munich Researchers Use WormLab to Study Blast Effects on C. elegans

by Pasang
in WormLab®, Scientific Applications & Use Cases, WormLab®Imaging System, MBF Products & Service Solutions, Additional Subject Matter, C.elegans Behavioral Analysis Solutions, C. Elegans, Worm Tracking
Comments

  Explosions can tear apart buildings, send shrapnel flying, and hurtle humans into the air. But explosions also cause damage in ways that aren't as visually apparent. Scientists say the force of a blast can cause brain damage, but questions linger about how the symptoms that emerge after a blast-induced traumatic brain injury are connected to the initial trauma.   In their quest to learn more about how symptoms...

Read More
August 14, 2015

First System for Imaging and Analyzing Large Mammalian Brain Tissue Installed in South Africa

by Pasang
in Company News, MBF Products & Service Solutions, Additional Subject Matter, Whole Brain Analysis, Whole Slide Imaging & Analysis, Microscopic Imaging & Analysis
Comments

[caption id="attachment_5991" align="aligncenter" width="632"] Dr. Paul Manger's new system developed by MBF Bioscience for analyzing large mammalian brain specimens[/caption]   Dr. Paul Manger, Research Professor at the University of the Witwatersrand, South Africa, studies the brain anatomy of various animals to better understand the relationship between brain structure and function. Some of the mammals he studies have very large brains that don't fit under a conventional research...

Read More
March 4, 2015

Hippocampal Neurons Change After Melatonin Injection

by Pasang
in Neurolucida®, Scientific Applications & Use Cases, Software & Microscope Integrated Systems, MBF Products & Service Solutions, Neuron Reconstruction
Comments

[caption id="attachment_5635" align="aligncenter" width="584"] Representative dendrites of dentate gyrus neurons of Siberian hamsters injected with melatonin (stained with Cresyl violet). Ikeno et al found hamsters injected with melatonin displayed decreased spine density on neurons in the dentate gyrus. Image courtesy of Tomoko Ikeno, Ph.D.[/caption]   Night falls and a powerful hormone called melatonin kicks in. The gears of the circadian clock are turning as you get ready...

Read More
February 17, 2015

Stereo Investigator continues to be the leading stereology system

by Pasang
in Company News, Scientific Applications & Use Cases, Software & Microscope Integrated Systems, Stereo Investigator®, MBF Products & Service Solutions, Additional Subject Matter, Stereology
Comments

In 2014 researchers used Stereo Investigator in 698 peer-reviewed papers - citing it almost three times more than all other stereology systems combined. Researchers tell us they use Stereo Investigator because: it works with many different microscopes and imaging technologies it provides unbiased data about neuron populations and regions of interest it comes with strong technical and research support provided by MBF Bioscience [caption id="attachment_5790" align="alignnone" width="1394"] source: google scholar[/caption] Dr. Mark West, co-developer of...

Read More
February 4, 2015

How Transplanted Stem Cells Behave in Injured Spinal Cord Tissue

by Pasang
in Stereo Investigator®, Scientific Applications & Use Cases, Software & Microscope Integrated Systems, MBF Products & Service Solutions, Additional Subject Matter, Stem Cell Research, Stereology
Comments

[caption id="attachment_5546" align="aligncenter" width="401"] A representative confocal image of spinal cord tissue fluorescently immunolabeled for SC121 (red) in conjunction with GFAP (green) – markers that allowed researchers to quantify stem cell differentiation and migration. (Image provided by study author Dr. Aileen J. Anderson)[/caption]   Research has shown that transplanting human neural stem cells into damaged spinal cords restores locomotor function in a mouse model of spinal cord injury1. Researchers...

Read More
January 23, 2015

Dendritic Spine Loss Reported in Schizophrenia and Bipolar Disorder

by Pasang
in Neurolucida®, Software & Microscope Integrated Systems, Scientific Applications & Use Cases, MBF Products & Service Solutions, Neuron Reconstruction
Comments

[caption id="attachment_5745" align="aligncenter" width="307"] Golgi-stained human brain tissue from the dorsolateral prefrontal cortex.[/caption] Schizophrenia and bipolar disorder are very different mental illnesses, but researchers are discovering evidence that the two disorders have some common pathologies. According to a recent study, a shared characteristic appears to be dendritic spine loss.   The researchers used Neurolucida to study pyramidal cells in human brain tissue from individuals with schizophrenia (n=14), individuals with bipolar...

Read More