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MBF Bioscience News

MBF Bioscience >  Blog
February 25, 2014

Researchers Restore Neuron Branching in Model of Mutant NHE6 Gene

by Pasang
in Additional Subject Matter, Autism
Comments

[caption id="attachment_5226" align="aligncenter" width="584"] Mice with the NHE6 gene mutation show less dendritic branching. Using Neurolucida, researchers traced a GFP-labeled neuron reconstructed with confocal z stacks in a wild type mouse (left) and a mouse with a mutant NHE6 gene (right). Image courtesy of first author Qing Ouyang, PhD, Alpert Medical School, Brown University.[/caption] Children with the neurogenetic disorder Christianson Syndrome experience delays in language and...

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February 10, 2014

Exercise Heals the Brain After Binge Drinking

by Pasang
in Software & Microscope Integrated Systems, Scientific Applications & Use Cases, Stereo Investigator®, MBF Products & Service Solutions, Additional Subject Matter, Stereology, Cavalieri Estimator, Optical Fractionator
Comments

[caption id="attachment_5185" align="aligncenter" width="584"] The granule cell layer of the dentate gyrus. Image provided by Mark Maynard.[/caption] Binge drinking damages brain regions responsible for memory, decision-making, and behavioral control. After a binge, the brain begins to heal itself but not much is known about this self-repair process. In a study published in PLoS ONE, researchers used rats to find that binge drinking damages the hippocampus, and...

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January 29, 2014

Neurons in the Basal Forebrain are Exquisitely Organized

by Pasang
in Neurolucida®, Software & Microscope Integrated Systems, Scientific Applications & Use Cases, MBF Products & Service Solutions, Additional Subject Matter, 3D Reconstruction, Neuron Reconstruction
Comments

The loss of cholinergic neurons is one of the earliest pathological events of Alzheimer’s disease. Cholinergic neurons in the basal forebrain supply the cerebral cortex with acetylcholine, an important neurotransmitter that plays a role in learning, memory, and attention. Details about the function and organization of basal forebrain (BF) neurons are not well understood, but Dr. Laszlo Zaborszky has recently uncovered new information about the...

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December 13, 2013

Scientists use Stereo Investigator to Discover that Part of the Hippocampus Shrinks in Socially Isolated Rodents

by Pasang
in Scientific Applications & Use Cases, Software & Microscope Integrated Systems, Stereo Investigator®, MBF Products & Service Solutions, Additional Subject Matter, Cavalieri Estimator, Stereology
Comments

Social isolation is stressful. Scientists have known it for decades. They also know that isolation causes changes to occur in the brains of rodents and primates. But most studies examine the effects of isolation during childhood; and the ones that do focus on adulthood tend to use male subjects. For the first time, researchers in Spain show that long-term social isolation causes part of the...

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November 21, 2013

Researchers from Quebec Delay Symptoms of Huntington’s Disease in Mouse Model

by Pasang
in Stereo Investigator®, Scientific Applications & Use Cases, Software & Microscope Integrated Systems, MBF Products & Service Solutions, Additional Subject Matter, Stereology, Optical Fractionator
Comments

A montage of three images of single striatal neurons transfected with a disease-associated version of huntingtin, the protein that causes Huntington's disease; By: Dr. Steven Finkbeiner, Gladstone Institute of Neurological Disease, The Taube-Koret Center for Huntington's Disease Research, and the University of California San Francisco; licensed under the Creative Commons Attribution 3.0 Unported license.   Patients with Huntington's disease deteriorate physically, cognitively, and emotionally. There is no cure for the inherited...

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October 22, 2013

Researchers use WormLab to reveal that nicotine addiction is heritable in C. elegans

by Pasang
in WormLab®, Scientific Applications & Use Cases, WormLab®Imaging System, MBF Products & Service Solutions, Additional Subject Matter, C.elegans Behavioral Analysis Solutions, C. Elegans, Worm Tracking
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Smokers aren't only hurting themselves, they're also hurting their children and grandchildren. So says a study published last month in the EXCLI Journal.   Scientists at East Carolina University, in Greenville, North Carolina saw unusual behavior in C. elegans roundworms exposed to nicotine at an early stage of development. But that's not all – the researchers also witnessed abnormal behavior and withdrawal symptoms in subsequent generations of...

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October 9, 2013

Scientists Discover Anorexia-Driven Changes to Dendrites With Neurolucida

by Pasang
in Neurolucida®, Scientific Applications & Use Cases, Software & Microscope Integrated Systems, MBF Products & Service Solutions, 3D Reconstruction, Neuron Reconstruction
Comments

  Gaunt facial features and a frighteningly thin figure are physical hallmarks of anorexia nervosa, an eating disorder that predominantly affects adolescent girls. But in addition to extreme weight loss, changes take place that aren't as visually apparent. For the first time, scientists in New York have found evidence of brain plasticity in the activity-based anorexia (ABA) mouse model.   Led by Dr. Chiye Aoki of New York...

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October 7, 2013

MBF customer Dr. Thomas Südhof wins Nobel Prize

by Pasang
in Additional Subject Matter, Awards
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The Nobel Prize in Physiology or Medicine was awarded to Drs. Thomas Südhof, James Rothman, and Randy Schekman for discovering the principles of how molecules are transported within cells and in between cells and how they are delivered to the right place at the right time. Disruptions in this precise system are implicated in numerous neurological and immunological disorders.     Dr. Sudhof uncovered how neurotransmitters are released into...

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September 25, 2013

Neurolucida Helps Scientists Discover that Gorillas are Relevant in the Study of Alzheimer’s Disease

by Pasang
in Neurolucida®, Scientific Applications & Use Cases, Software & Microscope Integrated Systems, MBF Products & Service Solutions, Additional Subject Matter, Alzheimer’s Disease, Neuron Reconstruction
Comments

Humans and gorillas are approximately 98% identical on a genetic level, however there is little published research exploring Alzheimer's disease pathology in gorillas. A new paper reports that gorillas display similarities in advanced age to humans  ̶  including the presence of Alzheimer's disease precursors like amyloid-beta (Aβ) plaques and tau lesions.   The study, published in the Journal of Comparative Neurology, provides evidence of Alzheimer's disease precursors in the western...

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September 19, 2013

Hawaii Scientists Measure Density of Parvalbumin-Interneurons With Stereo Investigator

by Pasang
in Stereo Investigator®, Scientific Applications & Use Cases, Software & Microscope Integrated Systems, MBF Products & Service Solutions, Stereology
Comments

Foods like tuna fish and Brazil nuts are rich in selenium, a mineral that scientists say has antioxidant effects, keeping the brain healthy and free of clutter so cells can work smoothly together. A key element of this process is Selenoprotein P (Sepp1) – a protein that delivers selenium to neurons by binding with another protein – ApoER2. Neuroscientists at the University of Hawaii say...

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