Scientific Applications & Use Cases

  When an adult rat learns new things about its physical environment, the newborn neurons in its brain change – dendrites branch, spines increase, soma grows. But what about mature neurons? Might they also undergo structural changes in response to learning? “Yes,” say scientists at the National Institute of Health and Medical Research and the University of Bordeaux, in Bordeaux, France.   Led by Drs. Valérie Lemaire, Sophie...

A rat uses its whiskers to get information about its environment. As it scurries along the subway tracks, or burrows into a dumpster, its whiskers send signals to ascending parts of its brain that let it know for example, whether it is safe to jump over that gap or not.   Scientists at the Max Planck Florida Institute are studying the functional responses of neurons in the...

Using Neurolucida, microscopy, and mice genetically engineered to express a random amount of red, yellow, and blue fluorescent proteins, Okinawa Institute of Science and Technology researcher Hermina Nedelescu has created a fascinating and hypnotic movie of neurons. Nedelescu and colleagues at the Institute's Computational Neuroscience Unit used Neurolucida and its Virtual Tissue 3D Extension Module and Montaging tools to acquire and stitch together multiple images of Purkinje cells—large neurons  that...

A willowy pair of pyramidal cells engage in an intricate dance with a dense mass of basket cells on the cover of the September 14, 2011 issue of the Journal of Neuroscience.   This exquisite image illustrates recent work by Columbia University researchers Dr. Adam M. Packer and Dr. Rafael Yuste, who used Neurolucida to study circuit connectivity in the mammalian neocortex.   According to the paper "Successfully filled...

No two trees are exactly alike, in the forest or in the brain. Though despite the diversity of dendritic arborizations, when it comes to branching out different types of neurons do have a couple things in common, say researchers at the National Institute for Physiological Sciences in Okazaki, Japan.   Led by longtime MBF Bioscience customer Dr. Yoshiyuki Kubota, the research team identified two organizational principles common...