We are pleased to announce the release of Neurolucida®version 2024.1.3, which introduces key updates to offline software licensing. These updates enhance the functionality and ensure uninterrupted use of the software on systems without internet access....
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We are pleased to announce that the International Neuroinformatics Coordinating Facility (INCF) has endorsed the MBF Bioscience neuromorphological file format as a standard. The file format is used in our products for neuroscience research for important applications such as digital neuron tracing, brain mapping and stereological analyses. MBF Bioscience products, including Neurolucida, Neurolucida 360, Stereo Investigator, Vesselucida 360, and NeuroInfo use this neuromorphological file format. This file...
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When we flex our thumb or point our finger, axons carry impulses from the brain to neurons in the spinal cord, which send messages to the muscles in our hands. In an important study in 1983, Jenny and Inukai at the Washington University School of Medicine reported the organizational patterns of those finger movement motoneuron columns in the primate spinal cord. Now, nearly 40 years...
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Researchers at Colorado College may have identified a new neuropathological hallmark of Chronic Traumatic Encephalopathy (CTE). Their findings, published in the Journal of Comparative Neurology, describe overall dendritic atrophy across cortical neurons and greater morphological variability in CTE brains compared to controls. A neurodegenerative disorder characterized by late-onset symptoms like depression, confusion, and memory loss, CTE is caused by repeated impacts to the brain. The disease...
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Neurolucida and Neurolucida Explorer Used for 3D Reconstruction and Quantitative Analysis Researchers used Neurolucida to reconstruct a newly discovered type of neuron found only in the human brain, according to a study published in the journal Nature Neuroscience. Known as “rosehip” neurons because of the way they resemble a rose after its petals have fallen off, these cells feature compact, bushy axonal arborizations. Found in the first...
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[caption id="attachment_6839" align="aligncenter" width="632"] Image Courtesy: Bob Jacobs, Ph.D. , Colorado College[/caption] With the release of its new version on November 28, NeuroMorpho.org adds 9,987 new images to its archive, bringing its impressive collection of digitally reconstructed neurons to 80,012. Scientists used MBF Bioscience’s software, Neurolucida and Neurolucida 360, to reconstruct the majority of these cells. In fact, 64 times more neurons were reconstructed with MBF Bioscience...
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[caption id="attachment_6830" align="aligncenter" width="632"] An experimental coronal mouse brain section automatically aligned to the Allen Mouse Brain Reference Atlas[/caption] Analyzing cellular populations within specific anatomies in brain images requires expertise in both neuroanatomy and cellular identification. This typically involves a scientist comparing experimental images with a reference atlas and manually delineating anatomical regions and marking cell populations within. NeuroInfo®, a revolutionary new technology from MBF Bioscience,...
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Neuroscientists can now analyze the size and complexity of neurons and collect unbiased stereology data with greater speed and efficiency We are happy to announce the release of Neurolucida and Stereo Investigator version 2017. This version features a completely revamped user interface that’s intuitive and easy to navigate. “Neurolucida and Stereo Investigator version 2017 are completely redesigned to improve the user experience and increase productivity,” said Jack...
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Astrocytes (GFAP) in the dentate gyrus of a mouse hippocampus. Image courtesy of Dr. Ahmad Salehi, Stanford University. It is well known that physical exercise eases the symptoms of neurodegenerative disorders like Alzheimer’s disease and helps to prevent their onset. Researchers at Stanford University are working on figuring out how it happens. In their study, published in the journal Brain Structure and Function, scientists in Dr....
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[caption id="attachment_6526" align="aligncenter" width="800"] Representative images of Iba-1+ microglia in the postnatal day 10 rat hippocampus. Image courtesy of Anna Klintsova, PhD.[/caption] Children born with fetal alcohol spectrum disorders face a range of physical and cognitive impairments including long-term deficits in learning, behavior, and immune function. In a paper published in Neuroscience, Dr. Anna Klintsova and her lab at the University of Delaware report that activation...
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