The developing and adult central nervous system of the mouse is complex and large. NIH Neuroscientist Dr. Charles Gerfen uses Neurolucida and NeuroInfo to collect, display, and share virtual slides with the research community. Recently, Dr. Gerfen requested software enhancements to better allow him to categorize and use his virtual slide data in mouse brain testing. We were happy to comply. Dr. Gerfen explains how he uses...
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Thousands of people in the United States have spinal cord injuries (SCIs), with associated loss of movement and sensation below the site of the injury. Neural and glial cell transplants into research animals after SCI have correlated with recovery of function. The improvement may be caused by the transplanted cells; it’s thought that remyelination by the transplanted glial cells is the main reason for the...
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Neurolucida is used for reconstruction and morphometric analysis of neurons and anatomical regions of interest. Neurolucida can also be used for quantitative and qualitative analysis of dendritic spines. Spines are small, often bulbous protrusions that emerge from the dendritic shaft. They are the main site of excitatory synapses in the brain [1], and they range in length from 0.001 to 1mm and range in diameter...
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Stereo Investigator Pulmonary Edition, our latest stereology software solution, is designed specifically to assist pulmonary researchers with quantitative stereological analysis. Stereo Investigator Pulmonary Edition introduces the Connectivity Assay. Using live video superimposed over captured images, pulmonary researchers can quickly mark bridges and islands. "Whether you’re counting alveoli or quantifying cells, lengths, or volumes, Stereo Investigator Pulmonary Edition’s intuitive workflow technology simplifies stereology," said MBF Bioscience President...
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Stereology allows us to estimate the amount and size of biological features that are impossible or prohibitive to measure exhaustively. If the stereological probe is designed well, and we can manage to follow all the rules, bias due to sampling design and estimation methods will be eliminated, resulting in a more accurate estimate. For instance, when using the Optical Fractionator to estimate the number of cells...
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Jack Glaser, president and founder of MBF Bioscience was named the 2007 Vermont Small Business Person of the Year by the US Small Business Administration. Glaser founded MicroBrightField (renamed MBF Bioscience in 2006) with his father, Dr. Edmund M. Glaser in 1987. Their goal was to develop powerful yet affordable neuroanatomical imaging software for the global research community. Today, MBF software is used by over 1000...
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