Life's little pleasures often elude those suffering from depression, including rats, who show little interest in sugar water after experiencing stress. This behavior leads scientists to speculate that the illness might be characterized by a defect in the brain's neural reward circuit. Recent research focuses on a key element of this circuit – the nucleus accumbens (NAc), part of the brain region known as the ventral...
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Scientists hypothesize that seizures occur because brain cells fire in places they're not supposed to. Dentate granule cells (DGCs), a type of neuron born throughout adulthood, sometimes migrate into a different region of the dentate gyrus, a part of the hippocampus. These abnormal newborn cells sprout axons called “mossy fibers” that form connections with neighboring DGCs in the inner molecular layer, causing synaptic changes that...
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The placenta delivers nutrients from a mother's blood to a developing fetus. It also produces hormones that help the baby grow during its forty or so weeks in utero. But the placenta's powerhouse abilities don't end there. The organ provides a wealth of information about the infant's future health, allowing doctors to make predictions about whether or not the child will develop autism or, later...
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If one area isn't working, another part can step in. Plasticity is one of the brain's most beautiful attributes. Recent research has documented the organ's ability to compensate in the face of damage, and now a new study identifies a key region for compensation when the damage occurs in the hippocampus. The region is the medial prefrontal cortex (mPFC). It's an integral part of the hippocampal-prefrontal-amygdala...
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Obstetricians and midwifes have long hailed the benefits of folic acid during pregnancy. Now new research offers evidence that choline is another important nutrient for the developing fetus. Found in foods like eggs and cauliflower, choline is known to aid healthy liver function. But in the past few years, studies have shown that the nutrient also plays a role in brain development. One recent study...
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According to scientists at the Hotchkiss Brain Institute in Calgary, Canada, there is evidence for increased neurogenesis in adult mice reared by two parents. Their study also describes other interesting findings, such as the fact that increased neurogenesis persists in the next generation, or that the effects of differences in rearing affect males and females differently. Using Stereo Investigator to perform a stereological assessment of proliferating cells...
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Researchers at the Waisman Center (University of Wisconsin-Madison) just took a big step in their quest to develop regenerative medicines for treating Parkinson's, Alzheimer’s, and other neurodegenerative diseases. They used human embryonic stem cells to restore memory and learning in disabled mice. The study, published last month in Nature Biotechnology, "is the first to show that human stem cells can successfully implant themselves in the brain...
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Spinal cord injuries can result in a range of physical disabilities from slight loss of motor function to major paralysis, but little is known about the mechanisms underlying the damage. Scientists affiliated with the Miami Project to Cure Paralysis at the University of Miami are gaining knowledge about how the nervous system responds to spinal cord injuries. Their latest study, published last month in the...
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What does it take to survive that tumultuous time called adolescence? Good friends, exercise, and new brain cells. Scientists at Michigan State University found evidence of neurogenesis in the brains of adolescent hamsters, according to a study published last month in PNAS. The new cells, which became integrated into neural circuits in adulthood, were discovered in the amygdala and connected limbic regions – areas associated with...
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The importance of studying the brain in three dimentions is something we understand at MBF Bioscience. Every day scientists around the world use our products to reconstruct neurons and analyze brain cells in 3D. That's why we're excited to hear about the new possibilities for whole brain analysis coming out of Dr. Karl Deisseroth's lab at Stanford University. A press release issued last week describes a...
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