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MBF Bioscience >  Blog > MBF Products & Service Solutions (Page 10)
November 21, 2013

Researchers from Quebec Delay Symptoms of Huntington’s Disease in Mouse Model

by Pasang
in Scientific Applications & Use Cases, Software & Microscope Integrated Systems, Stereo Investigator®, MBF Products & Service Solutions, Additional Subject Matter, Stereology, Optical Fractionator
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A montage of three images of single striatal neurons transfected with a disease-associated version of huntingtin, the protein that causes Huntington's disease; By: Dr. Steven Finkbeiner, Gladstone Institute of Neurological Disease, The Taube-Koret Center for Huntington's Disease Research, and the University of California San Francisco; licensed under the Creative Commons Attribution 3.0 Unported license.   Patients with Huntington's disease deteriorate physically, cognitively, and emotionally. There is no cure for the inherited...

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October 22, 2013

Researchers use WormLab to reveal that nicotine addiction is heritable in C. elegans

by Pasang
in WormLab®, WormLab®Imaging System, Scientific Applications & Use Cases, MBF Products & Service Solutions, Additional Subject Matter, C.elegans Behavioral Analysis Solutions, C. Elegans, Worm Tracking
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Smokers aren't only hurting themselves, they're also hurting their children and grandchildren. So says a study published last month in the EXCLI Journal.   Scientists at East Carolina University, in Greenville, North Carolina saw unusual behavior in C. elegans roundworms exposed to nicotine at an early stage of development. But that's not all – the researchers also witnessed abnormal behavior and withdrawal symptoms in subsequent generations of...

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October 9, 2013

Scientists Discover Anorexia-Driven Changes to Dendrites With Neurolucida

by Pasang
in Neurolucida®, Scientific Applications & Use Cases, Software & Microscope Integrated Systems, MBF Products & Service Solutions, 3D Reconstruction, Neuron Reconstruction
Comments

  Gaunt facial features and a frighteningly thin figure are physical hallmarks of anorexia nervosa, an eating disorder that predominantly affects adolescent girls. But in addition to extreme weight loss, changes take place that aren't as visually apparent. For the first time, scientists in New York have found evidence of brain plasticity in the activity-based anorexia (ABA) mouse model.   Led by Dr. Chiye Aoki of New York...

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September 25, 2013

Neurolucida Helps Scientists Discover that Gorillas are Relevant in the Study of Alzheimer’s Disease

by Pasang
in Neurolucida®, Scientific Applications & Use Cases, Software & Microscope Integrated Systems, MBF Products & Service Solutions, Additional Subject Matter, Alzheimer’s Disease, Neuron Reconstruction
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Humans and gorillas are approximately 98% identical on a genetic level, however there is little published research exploring Alzheimer's disease pathology in gorillas. A new paper reports that gorillas display similarities in advanced age to humans  ̶  including the presence of Alzheimer's disease precursors like amyloid-beta (Aβ) plaques and tau lesions.   The study, published in the Journal of Comparative Neurology, provides evidence of Alzheimer's disease precursors in the western...

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September 19, 2013

Hawaii Scientists Measure Density of Parvalbumin-Interneurons With Stereo Investigator

by Pasang
in Software & Microscope Integrated Systems, Stereo Investigator®, Scientific Applications & Use Cases, MBF Products & Service Solutions, Stereology
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Foods like tuna fish and Brazil nuts are rich in selenium, a mineral that scientists say has antioxidant effects, keeping the brain healthy and free of clutter so cells can work smoothly together. A key element of this process is Selenoprotein P (Sepp1) – a protein that delivers selenium to neurons by binding with another protein – ApoER2. Neuroscientists at the University of Hawaii say...

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September 17, 2013

Ohio State Neuroscientists Use Neurolucida to Analyze Brain Cells in Sexually Active Hamsters

by Pasang
in Software Applications For Quantitive Analysis, Neurolucida®, Software & Microscope Integrated Systems, Scientific Applications & Use Cases, MBF Products & Service Solutions, Additional Subject Matter, Neurolucida®Explorer, 3D Reconstruction, Neuron Reconstruction
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Scientists hypothesize that during puberty, experiences influence brain development in ways that shape brain structure and even behavior in adulthood. One type of experience that often arises in the minds of pubescent teens and adolescents is sex. But a study published in the journal Hormones and Behavior suggests engaging in sexual activity too soon could be detrimental to the adult brain, and may lead to...

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August 30, 2013

New Zealand Scientists Use Stereo Investigator to Develop a New Model for Human Extreme Prematurity

by Pasang
in Scientific Applications & Use Cases, Software & Microscope Integrated Systems, Stereo Investigator®, MBF Products & Service Solutions, Additional Subject Matter, Cavalieri Estimator, Stereology, Optical Fractionator
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Each year, nearly ninety thousand children are born extremely premature in the United States – that is, before 28 weeks gestation. Most of them survive, but about half the survivors suffer from severe health problems throughout their childhood and into adulthood, including learning and behavioral disorders such as ADHD.   “Treatment options are clearly urgently required to prevent the brain damage and associated memory deficits that follow...

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August 22, 2013

Scientists Assess Kidney Damage with Stereo Investigator, Determine Ultrasound Prevents Organ Injury

by Pasang
in Scientific Applications & Use Cases, Software & Microscope Integrated Systems, Stereo Investigator®, MBF Products & Service Solutions, Stereology
Comments

When it comes to health, kidneys are critical. From regulating blood composition to maintaining calcium levels, the pair of bean-shaped organs perform several essential tasks. Needless to say, interruption to kidney function can be disastrous.   Working with scientists in South Korea, researchers at the University of Virginia found a surprisingly simple treatment for renal ischemia-reperfusion injury (IRI) in mice, which is a model of acute kidney...

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August 8, 2013

Japanese Researchers Develop New Optical Clearing Agent; Neurolucida Used For 3D Imaging in Study

by Pasang
in Neurolucida®, 2 Photon, Software & Microscope Integrated Systems, Scientific Applications & Use Cases, MBF Products & Service Solutions, Additional Subject Matter, 3D Reconstruction, Neuron Reconstruction
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A new optical clearing agent developed by scientists in Japan clears brain tissue samples with greater transparency and less time than other clearing agents, according to a paper published in Nature Neuroscience.   “Combined with two-photon microscopy, SeeDB allowed us to image fixed mouse brains at the millimeter-scale level,” say the authors, who after clearing the brain tissue with SeeDB, captured images with a multiphoton Olympus microscope,...

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August 7, 2013

Drug for Treating Asthma Improves Cognitive Function in Down Syndrome Mouse Model

by Pasang
in Neurolucida®, Scientific Applications & Use Cases, Software & Microscope Integrated Systems, MBF Products & Service Solutions, Additional Subject Matter, 3D Reconstruction, Neuron Reconstruction
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Researchers at the Stanford University School of Medicine have found that formoterol ̶  an FDA-approved drug for treating asthma and similar respiratory disorders ̶  improves cognitive function in mice genetically altered to exhibit symptoms of Down syndrome including cognitive disability.   Formoterol was chosen for the study because it activates β2 adrenergic receptors (β2ARs) on neurons, a task also carried out by norepinephrine, a neurotransmitter with a...

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