Dr. Daniel Peruzzi, staff scientist, shares his thoughts below: Customers often ask Staff Scientists at MBF Bioscience why it is sometimes difficult to reproduce certain published stereological results. For example, we get the question, “The estimates that I make of cell number in the region I’m researching do not match numbers reported in the literature. Can you help me understand why?” To solve this dilemma, we encourage...
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During a chicken embryo's twenty-one days of incubation, its eyes develop in astonishing ways. Muscles form, neurons branch, innervation occurs. Researchers at Dr. Rae Nishi's lab at the University of Vermont, including two MBF Bioscience staff scientists Julie Simpson, Ph.D. and Julie Keefe, M.S. are studying the development of a chicken embryo's nervous system. Their specific focus is on the behavior of neurons in the...
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When an adult rat learns new things about its physical environment, the newborn neurons in its brain change – dendrites branch, spines increase, soma grows. But what about mature neurons? Might they also undergo structural changes in response to learning? “Yes,” say scientists at the National Institute of Health and Medical Research and the University of Bordeaux, in Bordeaux, France. Led by Drs. Valérie Lemaire, Sophie...
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Rats lose brain cells as they get older. But that doesn't mean they can't find their way through a water maze as quickly as their younger cohorts can. Using unbiased stereology to quantify neurons in the prefrontal cortex of young and old rats, scientists at John Hopkins University in Baltimore found the total neuron number in the dorsal prefrontal cortex (dPFC) decreases with age. But despite...
Read More In the period of juvenile life, between birth and adulthood, a mouse brain adds a significant number of new neurons; nearly doubling their number in some regions. Researchers at the University of California Los Angeles published their findings last week in Frontiers in Behavioral Neuroscience. Their findings showed that these new neurons may aid in the development of several cognitive skills. Using a transgenic mouse model...
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A rat uses its whiskers to get information about its environment. As it scurries along the subway tracks, or burrows into a dumpster, its whiskers send signals to ascending parts of its brain that let it know for example, whether it is safe to jump over that gap or not. Scientists at the Max Planck Florida Institute are studying the functional responses of neurons in the...
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Using Neurolucida, microscopy, and mice genetically engineered to express a random amount of red, yellow, and blue fluorescent proteins, Okinawa Institute of Science and Technology researcher Hermina Nedelescu has created a fascinating and hypnotic movie of neurons. Nedelescu and colleagues at the Institute's Computational Neuroscience Unit used Neurolucida and its Virtual Tissue 3D Extension Module and Montaging tools to acquire and stitch together multiple images of Purkinje cells—large neurons that...
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A willowy pair of pyramidal cells engage in an intricate dance with a dense mass of basket cells on the cover of the September 14, 2011 issue of the Journal of Neuroscience. This exquisite image illustrates recent work by Columbia University researchers Dr. Adam M. Packer and Dr. Rafael Yuste, who used Neurolucida to study circuit connectivity in the mammalian neocortex. According to the paper "Successfully filled...
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No two trees are exactly alike, in the forest or in the brain. Though despite the diversity of dendritic arborizations, when it comes to branching out different types of neurons do have a couple things in common, say researchers at the National Institute for Physiological Sciences in Okazaki, Japan. Led by longtime MBF Bioscience customer Dr. Yoshiyuki Kubota, the research team identified two organizational principles common...
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