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Neurolucida®360

MBF Bioscience >  Blog > MBF Products & Service Solutions  > Software Applications For Quantitive Analysis  > Neurolucida®360
December 28, 2023

From Proteins to Dendritic Spines: Neurolucida 360 Plays a Crucial Role in Advancing Neuroscience

by Pasang
in Software Applications For Quantitive Analysis, MBF Products & Service Solutions, Neurolucida®360, Neurolucida®Explorer
Comments

In the fast-evolving field of neuroscience, groundbreaking research on the intricate workings of the vertebrate brain yields new information every day. A recent study published in the Journal of Neuroscience describes the establishment of an approach for better contextualization of proteins identified through proteomic analyses to identify candidate proteins for functional validation testing. The authors examined human synaptic processes from well-characterized human post-mortem samples and...

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June 28, 2022

Blue Brain scientists develop pyramidal cell classification system using neurons reconstructed with Neurolucida 360

by Pasang
in Software Applications For Quantitive Analysis, MBF Products & Service Solutions, Neurolucida®360
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After decades of identifying brain cells subjectively, researchers can now make use of a standardized classification system for identifying pyramidal cells—the most common type of cells in the neocortex. Scientists at the Blue Brain Project developed the system using mathematics that identify the properties of shapes that stay constant under continuous transformation. This new method of classification gives researchers the ability to begin building a...

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March 21, 2022

INCF endorses the MBF Bioscience neuromorphological file format

by Pasang
in Software Applications For Quantitive Analysis, Neurolucida®, Company News, Software & Microscope Integrated Systems, Stereo Investigator®, MBF Products & Service Solutions, NeuroInfo®, Additional Subject Matter, Neurolucida®360, Vesselucida®360
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We are pleased to announce that the International Neuroinformatics Coordinating Facility (INCF) has endorsed the MBF Bioscience neuromorphological file format as a standard.   The file format is used in our products for neuroscience research for important applications such as digital neuron tracing, brain mapping and stereological analyses. MBF Bioscience products, including Neurolucida, Neurolucida 360, Stereo Investigator, Vesselucida 360, and NeuroInfo use this neuromorphological file format.   This file...

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September 23, 2020

Curcumin Lowers Neuroinflammation in Mouse Model

by Pasang
in Software Applications For Quantitive Analysis, Software & Microscope Integrated Systems, Stereo Investigator®, MBF Products & Service Solutions, Additional Subject Matter, Neurolucida®360, Alzheimer’s Disease
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Scientists at Western Sydney University used Stereo Investigator and Neurolucida 360 to quantify cells in a mouse model of neuroinflammation after feeding mice two different curcumin formulations. Some inflammation is normal in a healthy mammalian brain. But as the brain ages, processes can break down, leading to chronic neuroinflammation. This can develop into Alzheimer’s disease, dementia, and other neurodegenerative diseases.   Scientists at Prof. Gerald Muench’s lab, at...

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March 2, 2020

Researchers Identify Potential Treatment for Patients at Risk for Alzheimer’s Disease

by Pasang
in Software Applications For Quantitive Analysis, MBF Products & Service Solutions, Additional Subject Matter, Neurolucida®360, Alzheimer’s Disease
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Neurolucida 360 Used to Analyze Dendrites and Dendritic Spines Amyloid plaques and tau tangles are the hallmarks of Alzheimer’s disease (AD) pathology, but synapse loss is what causes cognitive decline, scientists say. In a paper published in Science Signaling, researchers at the Herskowitz Lab, at the University of Alabama at Birmingham, used Neurolucida 360 to analyze spine density and dendritic length in hAPP mice — a...

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January 18, 2019

MBF Bioscience research team contributes novel dendritic spine analysis in study published in Science

by Pasang
in Software Applications For Quantitive Analysis, Company News, Software & Microscope Integrated Systems, Stereo Investigator®, MBF Products & Service Solutions, Additional Subject Matter, Neurolucida®360
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Combination of new microscopy and expansion tissue preparation methods facilitate better and faster analysis of subcellular neural elements. Today, the journal Science published a paper authored by a research team led by Dr. Ed Boyden of MIT and Nobel Prize recipient Dr. Eric Betzig of Janelia Research Campus. Among the authors are MBF Bioscience Scientific Director Dr. Susan Tappan and Senior Software Engineer Alfredo Rodriguez. In the...

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January 8, 2019

MBF Bioscience receives NIH funding to support innovative research program on the peripheral nervous system

by Pasang
in Company News, Software Applications For Quantitive Analysis, Press Release, MBF Products & Service Solutions, Additional Subject Matter, Neurolucida®360, TissueMaker®
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FOR IMMEDIATE RELEASE MBF Bioscience Williston, VT – January 9, 2019 – MBF Bioscience is pleased to announce our participation in the Stimulating Peripheral Activity to Relieve Conditions (SPARC) program. Funded by the National Institutes of Health (NIH), this extensive research initiative is a vast collaborative effort, which aims to deepen the understanding of how the peripheral nervous system impacts internal organ function.   “We are honored to be working...

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November 30, 2017

NeuroMorpho.Org Releases Nearly 10,000 New Neuron Reconstructions and Neurolucida leads the way

by Pasang
in Software Applications For Quantitive Analysis, Neurolucida®, Software & Microscope Integrated Systems, Scientific Applications & Use Cases, MBF Products & Service Solutions, Neurolucida®360, 3D Reconstruction, Neuron Reconstruction
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[caption id="attachment_6839" align="aligncenter" width="632"] Image Courtesy: Bob Jacobs, Ph.D. , Colorado College[/caption]   With the release of its new version on November 28, NeuroMorpho.org adds 9,987 new images to its archive, bringing its impressive collection of digitally reconstructed neurons to 80,012.   Scientists used MBF Bioscience’s software, Neurolucida and Neurolucida 360, to reconstruct the majority of these cells. In fact, 64 times more neurons were reconstructed with MBF Bioscience...

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March 24, 2017

A complete guide to imaging and analyzing spines and neurons with Neurolucida 360

by Pasang
in Software Applications For Quantitive Analysis, Scientific Applications & Use Cases, MBF Products & Service Solutions, Additional Subject Matter, Neurolucida®360, 3D Reconstruction, Neuron Reconstruction
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Following a well-designed protocol is essential to achieving accurate and consistent results in scientific research. Now, scientists using Neurolucida 360 for dendritic spine and neuron analysis can follow a published set of guidelines to ensure optimal confocal data series for proper dendritic spine quantification and neuron reconstruction. The paper, written by MBF Bioscience scientists and researchers from the Icahn School of Medicine at Mount Sinai...

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May 26, 2016

Neurolucida 360 v2.7: A minor release with major new features

by Pasang
in Software Applications For Quantitive Analysis, Company News, MBF Products & Service Solutions, Additional Subject Matter, Neurolucida®360
Comments

The 3 algorithms in Neurolucida 360 were used in combination to create a smooth, accurate reconstruction   Minor releases typically don't include new features, but Neurolucida 360 isn't an ordinary piece of software. Neurolucida 360 v2.7 has many new features and improvements, including: A new automatic tracing algorithm - Rayburst Crawl Capture videos of your rotating neuron reconstructions for presentations and publications New backbone length analysis for dendritic spines Improved handling of images...

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